top of page

UltraView

for Cellular Metabolism

Application Overview

Laser-based infrared microscopy can achieve label-free, high-sensitivity, and high-speed video-rate mid-infrared imaging. It allows real-time observation of rapid dynamic processes of different organelles, proteins, lipid droplets, etc., within live cells, providing an important tool for cell dynamics research. Compared to traditional fluorescence imaging, it has advantages such as being non-destructive, label-free, and possessing strong component analysis capabilities.​​​

Typical Example

By using two sets of Galvo mirrors to synchronously scan mid-infrared excitation light and visible probe light, a scanning speed exceeding 2kHz was achieved, ensuring uniform illumination over a large field of view. No obvious photodamage was observed during the imaging process of live samples, enabling long-term, non-destructive imaging.

application-cellular-metabolism-1.jpg
Laser-based infrared microscopy enables imaging of components such as proteins and lipid droplets in live tumor cells and live nematodes.
Yin, J. et al. Video-rate mid-infrared photothermal imaging by single-pulse photothermal detection per pixel. Science Advances 9, eadg8814 (2023).
bottom of page